Radium 223 is approved

For those of us who grew up in a certain era, the memory of “downwinders” will be etched in our cold war memories. The strontium -90 that found its way into bone was not good, but it did give rise to Sr-89 which has been used for more than a decade to treat bone metastases, especially for pain in patients who have one painful spot after another and this can replace going back and forth to an external beam facility.

Radium, the Nobel Prize winning isotope for Madame Curie, has several isotopes, one of which, Radium-223 has now been approved for treating prostate cancer. The main difference from Strontium or Samarium (another approved isotope) is that it is an alpha emitter. Alpha particles are in the category of “high LET” radioisotopes meaning they deliver enormous amounts of energy over short distances. Due to their mass, they also do not travel “through” most materials, but are stopped by the nucleus of most atoms. Thus a sheet of paper can significantly stop alpha particles, while beta particles, the main energy of Sr and Sm, travel farther, and deliver somewhat less energy.

The good news here, is that Radium 223, now dubbed “xofigo” (don’t ask me where the pharmas come up with these names except that all the ones starting with A-W must be taken…seriously…”xgeva”, “zytiga”…you must be kidding) has now been approved for treating prostate cancer bone metastases and is the first isotope to show prolongation of survival. Rather than rewriting a nice news report in Medscape, I will simply quote it here. You may be able to sign on to Medscape and read it there for yourself, but here is the quote:

A novel radiopharmaceutical agent has been approved by the US Food and Drug Administration (FDA) for use in the treatment of prostate cancer.

The product, radium-223 dichloride (formerly known as alpharadin), will be marketed as Xofigo by Bayer for use in men with symptomatic metastatic castration-resistant prostate cancer that has spread to the bone but not to other organs. It is intended for men whose cancer has spread after medical or surgical therapy to lower testosterone, according to the FDA.

The FDA reviewed the product under its priority program, which provides for an expedited review of drugs that appear to provide safe and effective therapy when no satisfactory alternative therapy exists or offer significant improvement over products on the market. It was approved more than 3 months ahead of schedule.

Radium-223 dichloride “binds with minerals in the bone to deliver radiation directly to bone tumors, limiting the damage to the surrounding normal tissues,” said Richard Pazdur, MD, director of the Office of Hematology and Oncology Products at the FDA Center for Drug Evaluation and Research.

The product, administered once a month by intravenous injection, contains the heavy metal radium, which is taken up by osteoblasts and then emits alpha radiation. This causes double-strand DNA breaks that are lethal to the prostate cancer cell at the site of increased bone turnover induced by the cancer.

In a Medscape video commentary, Johann de Bono, MBChB, PhD, MSc, from the Royal Marsden NHS Foundation Trust in Sutton, United Kingdom, explained that radium-223 dichloride has minimal myelosuppression, is very well tolerated, and shows an impressive overall survival benefit.

The survival data come from the pivotal phase 3 ALSYMPCA trial, which involved 809 prostate cancer patients who were resistant to hormone treatment and had developed 2 or more bone metastases. All of the participants received standard treatment, but the men who also received radium-223 chloride lived significantly longer. An interim analysis revealed a median overall survival of 14.0 months, compared with 11.2 months (hazard ratio, 0.695; P = .00185), and the trial was stopped because of benefit.

An exploratory updated analysis confirmed the product’s ability to extend overall survival, according to the FDA.

The most common adverse effects of radium-233 dichloride seen during clinical trials were nausea, diarrhea, vomiting, and swelling of the leg, ankle, or foot.

Radium-223 dichloride is highly targeted for bone metastases, so it is possible that it could be used in many different cancers that have spread to the bone, regardless of primary site, said lead investigator Chris Parker, MD, consultant clinical oncologist at the Royal Marsden Hospital in London, United Kingdom. Prostate cancer patients were studied in the first instance because this cancer has a high tendency to metastasize to the bone, Dr. Parker explained. About 90% of patients with advanced prostate cancer will develop bone metastases and, in many cases, there will not be any detectable metastases elsewhere in the body, he said.

This brings to about 7, the number of new drugs we have for treating advanced prostate cancer in the past few years. Great news for our patients, especially if we can figure out a way to get the costs under control.

 

6 Comments

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6 responses to “Radium 223 is approved

  1. Dr. Mike,
    As you know I’m in the last dose in series of 6 infusions of Radium 223. I can say the Radium 223 has improved my met pains. Since January of this year I’ve been on FDA’s “Early Expanded Access” program of Radium 223 knowing the FDA has “fast Tracked” this new breakthrough drug. Radium 223 is called “the liquid radiation” as it’s infused into the blood stream. Out of 5 infusions, I came back the same day (3) times from Vegas and set off the TSA machine all (3). (2) times I came back 2 or 3 days later and did not set off the radiation detector! I call it,”going nuclear”! I’m aware of the big (4) new breakthrough PCa drugs,(Provenge, Zytiga, Xtandi and Radium 223) but you said there were (7)? What are the other (3)? Thanks, Craig

    • Denosumab, cabazitaxel, and in the pipeline phase III, cabozantinib (already approved for medullary carcinoma of thyroid). Further pipeline drugs include Prostvac, ARN 509, TAK 001, possibly ipilimumab, OGX-011, and capesaris (among many others).

  2. Scott Kayser

    Mike:

    I don’t know if one is to respond re: personal situation, if so, where does this fit into my current regimen?

    Scott K.

  3. Pingback: Finally A List of New Breakthrough Drugs For Prostate Cancer! | New Denver Men's Club

  4. Cindy Landsberg

    Just wanted to say I wish we had subscribed to your blog 4 years ago. You communicate so well both in person and in writing. Much more concise and wry than wading through all the abstracts from uro today. We are lucky to have you as our physician. Thanks for putting out this blog. Cindy

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