Multivitamins and Green Tea and (whatever…)

The scientific writers of articles for radio, TV, and newspapers seem to love to write about supplements and cancer. There are good reasons for this. Studies have shown that well over a third of cancer patients start taking dietary supplements after their diagnosis. These studies generally find that the practice is more common among women than men, among more highly educated patients, among older than younger, and is highly correlated with indices of patients wanting to have more control. Thus, a study that purports to find that some easily available dietary product slows or reduces cancer is bound to find a wide audience – after all, more than 1 in 3 of us has a personal relative with cancer or have a cancer diagnosis ourselves. Moreover, we are dealing with an industry that generates $27B in revenue in the U.S. alone.

This week’s literature provides two additional “newsworthy” examples of the phenomenon. In a huge study of physicians over the age of 50, with high compliance in taking either a multivitamin or placebo, there was a reduction in the rate of developing cancer. Of course when you get 14,000 men in a study, the ability for statistics to pick up a small difference may be too powerful. In this case, the reduction from 18.3 cases per 1000 person-years to 17 cases is certainly not very high. As I have often said in this blog, the eye of the beholder is critically important in deciding whether something is meaningful. For those with a discerning eye, they will note by reading the link to the PHS II study, that there was no difference in the rate of developing prostate cancer. For the record, I participated in the study and I received a letter this week stating I was on “active” multivitamins.

A second story making the rounds at present has to do with green tea. The UCLA group evaluated 34 men who drank 6 cups of green tea daily prior to prostatectomy and compared them to 33 men who drank only water in the same quantity. They found that PSA values declined and that some of the markers of prostate cancer cell proliferation changed in a healthy direction. This is but one of a long line of studies from this group indicating a potential positive effect. However, jumping from this to whether YOU should be drinking green tea in such prodigious quantities is another matter altogether. Before you buy any of the “we’ve found the answer” type of articles found in the lay press, I always suggest doing your own research. MY suggestion is to do this at Google Scholar. If you enter “tea” and “prostate cancer” you might find some surprises like this one which showed increased prostate cancer in tea drinkers in Scotland. However that was black tea probably, and for the most part, the green tea story seems to be a valid one. I’m just not sure the difference in things like molecular markers and PSA will really amount to anything in the way of improved survival or actually slowing the cancer down.

You could say, “yes, but it can’t hurt”, in which case I would be very cautious since studies of this sort seldom look at interactions with things we know DO help. For example, what would the effects of drinking lots of green tea be on abiraterone, or on enzalutamide, docetaxel, leuprolide, or on your immune system. Mostly unknown. Still, I generally tell my patients that low fat diets, lycopenes, pomegranate juice, and green tea all have some studies supporting their use. And for the most part, many patients try these, but we really don’t know which, if any, patients really benefit.

9 Comments

Filed under General Prostate Cancer Issues, Uncategorized

9 responses to “Multivitamins and Green Tea and (whatever…)

  1. Joe Blue

    Is the evidence for soy more or less compelling that for lycopenes, green tea, low fat diets and pomegranate juice? Thanks.

  2. marshall

    Good, good, goood stuff. Gzr

  3. Ashton Vilars

    Dr. Glode, There have been many articles written about oxygen and alkalinity helping to kill cancer cells. Any basis for these claims?
    Also sugar it is wide spread in alot of the literature that sugar feeds cancer as evidenced by glucose being used as a n uptake solution for finding cancer.
    Your comments?

    ashton

  4. Ashton Vilars

    Dr. Glode.
    What dosage was/is used in your ACAI juice study? I have been using 2-3 ounces/daily.
    Thanks Ashton

    • We have studied Acai juice at 2 ounces twice a day. An abstract has been submitted showing some activity but no public information yet on the study. As for “sugar/glucose feeds cancer” it is a classic case of “a little information…” Long ago it was realized that cancer cells utilize glucose in what is called the “Warburg effect”. This is one of the reasons glucose based PET scans work for some tumors. Unfortunately they don’t work very well for prostate cancer, and in fact, one of the more interesting things about prostate cancer is that if anything, it tends to use lipids more than glucose. I recommend low fat diets which have been shown to slow pca down. Even if you thought you could do something about cancer by eating fewer carbs, it is not likely to affect glucose levels much. The brain is totally dependent on glucose, so the body vigorously defends blood glucose levels and keeps them high enough for any cancer to do just fine. If you got your glucose levels low enough to stop cancer growth, you would have seizures.

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  7. Dr. Glode,
    Re glucose and cancer progression. I had early stage diabetic retinopathy, although glucose load tests showed me normal (I think due to “hyperglycaemic memory”). One of the things I did was to lower glucose spikes after meals, by walking, and by adopting a low carb (about 10% calories) diet involving a lot of greens, which I maintain (it makes recent weight losses very easy to obtain). I had very rapid and striking remission, and 4 years later am down to “just one dot”. Papers in that area say that the spikes account for 27% to 35% of glucose integral against time (which the Hb1AC measures). That’s a big effect, which could affect PC progression. I realise that the prostate will probably see most of the glucose output of the liver following lipid release signalled by the brain, for example at 4am. when diabetics are known to get “early morning rise”, so I am urgently losing (I hope visceral) fat to reduce my cancer risk in general.
    I have found that Kegel exercises cause a dramatic improvement in urine flow, ejaculate volume and recovery time, even though I was virtually symptomless. No papers seem to discuss the exercises apart from muscle-building in the abdominal floor. But my experience suggests a much improved blood flow to urogenital organs, which might remove hypoxia in any developing tumours, avoiding new vascularisation, volume growth and metastasis. The lack of research puzzles me. I have a friend with a high PSA figure, who is looking for things to do to improve his chances.

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